Real runs, unedited

HER2 expression across GTEx tissues, live from the GTEx API

class lookup · standard model · 2 min wall time · 16 tool calls · 7 artifacts · 58k tokens

Prompt: “Plot median expression of HER2 across GTEx tissues, highlight the top 5.”

Dose-response fit from eight numbers in the prompt

class specialist · standard model · 3 min wall time · 14 tool calls · 6 artifacts · 59k tokens

Prompt: “Fit a four-parameter logistic curve to this dose-response data (concentration in nM, % inhibition; duplicates): 0.1: 2, 4 · 0.3: 5, 7 · 1: 14, 18 · 3: 38, 42 · 10: 66, 70 · 30: 87, 89 · 100: 96, 97 · 300: 98, 99. Report IC50 with a 95% confidence interval and the Hill slope, make one figure with the points, the fitted curve and the IC50 marked, and save the fitting script.”

QC of a CRO IC50 deliverable (NCI-N87, two ADC candidates + benchmark + control)

class specialist · standard model · 11 min wall time · 34 tool calls · 8 artifacts · 173k tokens

Prompt: “Take this data from the CRO and QC it and return a summary of the results.”

Inputs: 20260531_STUDY-01_2D cell proliferation assay_NCI-N87_IC50.xlsx

Proteins of unknown function in extremophiles: the MEMO1 family across the three domains of life

class research · frontier model · 39 min wall time · 90 tool calls · 48 artifacts · 1.11M tokens

Prompt: “Give me an example of some proteins of unknown function in extremophiles. Choose the most interesting, and build a phylogenetic tree with related sequences across all domains of life, trace the evolution of key catalytic residues, and infer ancestral functions. In your final summary, don't include markdown links to raw data files larger than ~1 MB — reference them by name instead.”